Case 2
Result
Great: this is correct!
This biopsy case shows abundant invasive tumor with some necrosis. Non-neoplastic breast epithelium is also present. Patchy variable cytoplasmic blush is seen (even from lower magnification). Patchy faint to moderate partial membrane staining is seen. A rare tumor cell shows complete membrane staining. While some tumor cell membrane staining can be seen at a lower magnification, it is necessary to review the tissue at 40x to include all faint membrane staining. This case is challenging with 20% tumor cell membrane staining and was scored as HER2 IHC Score 1+.
This case has a
Score of IHC-1+ and hence is
IHC-1+= HER2 negative2
or HER2-low3,4
1. Ventana 4B5 Interpretation Guide (Roche) https://diagnostics.roche.com/us/en/landing-pages/breast-her2-low.html. 2. Wolff AC, et al. J Clin Oncol. 2023. 41(22):3867-3872. 3. ESMO Living Guidelines: https://www.esmo.org/living-guidelines/esmo-metastatic-breast-cancer-living-guideline. 4. Tarantino P, et al. Annals of Oncology. 2023. 645-659.
This tool has been developed by AstraZeneca and is for demonstration purposes, it is not meant to replace HER2 interpretation trainings.
The tool is intended for pathologists only.
Contact Us
Legal notice
Privacy Policy
Cookie policy
Report a possible side effect