Case 3
Result
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Abundant invasive tumor with cytoplasmic blush is seen, making discernment of true faint to weak membrane staining difficult and requiring examination at 40X. Staining along open spaces is present and is not included in HER2 scoring if there is no other tumor cell membrane staining. This is not included in HER2 scoring. Overall, this case shows 35% partial tumor cell membrane staining and was scored as HER2 IHC Score 1+.1
This case has a
Score of IHC-1+ and hence is
IHC-1+= HER2 negative2
or HER2-low3,4
1. Ventana 4B5 Interpretation Guide (Roche) https://diagnostics.roche.com/us/en/landing-pages/breast-her2-low.html. 2. Wolff AC, et al. J Clin Oncol. 2023. 41(22):3867-3872. 3. ESMO Living Guidelines: https://www.esmo.org/living-guidelines/esmo-metastatic-breast-cancer-living-guideline. 4. Tarantino P, et al. Annals of Oncology. 2023. 645-659.
This tool has been developed by AstraZeneca and is for demonstration purposes, it is not meant to replace HER2 interpretation trainings.
The tool is intended for pathologists only.
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