Case 4
Result
Unfortunately
this is not correct!
This is a challenging biopsy case with tumor showing cytoplasmic blush. While some membrane staining is apparent at 10x, as the tissue is examined at 20x and then 40x, more faint to weak partial membrane staining becomes apparent.
1. Ventana 4B5 Interpretation Guide (Roche) https://diagnostics.roche.com/us/en/landing-pages/breast-her2-low.html. 2. Denkert, C., Lebeau, A., Schildhaus, H.U. et al. Neue Therapiemöglichkeiten beim metastasierten HER2-low-Mammakarzinom. Pathologie 43, 457–466 (2022). https://doi.org/10.1007/s00292-022-01124-x
This tool has been developed by AstraZeneca and is for demonstration purposes, it is not meant to replace HER2 interpretation trainings.
The tool is intended for pathologists only.
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